Anthropological genetic genealogy is the application of genetics to traditional genealogy, involving the use of family history and DNA testing to determine the level of genetic relationship between individuals. The New Mexico DNA Project was started in 2004 to help individuals with roots to New Mexico confirm and validate genealogical research. The project consists of more than 2600 DNA samples of descendants of the first Spanish colonists to New Mexico. The lecture will begin with the first Spanish families and their genetic results. Questions of how they match, what ancestral origin they have before the forming of the colony, and how anthropological genetic genealogy works in confirming family history research will all be answered.